https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26175 Sat 24 Mar 2018 07:30:07 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28424 Sat 24 Mar 2018 07:29:02 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46647 in situ ocular gels containing sufacetamide sodium using pH induced gelling polymers for improved therapeutic response and patient compliance. Methods: In situ gel formulations prepared by dispersion method using Carbopol® 940/Carbopol® 934 alone or in combination with hydroxypropyl methylcellulose (HPMC E4M). Formultaions were evaluated for appearance, pH, viscosity, gelling capacity, drug content and in vitro drug release. The optimized formulation was assessed for sterility and antimicrobial efficacy using disk diffusion technique in comparison to commercial eye drops (Albucid®10%). Results: The appearance of in situ gels were clear and free flowing in nature however, a viscous clear solution with no flow was produced for formulations consisting of 0.8% w/v Carbopol® 940/Carbopol® 934 and 2% w/v HPMC E4M. pH of all the formulations was within the range of 5.9 to 6.7. In situ gels with Carbopol® 940 demonstrated higher viscosity compared to Carbopol® 934 and drug release was sustained over a period of 8 h. The selected formulation containing 0.8% w/v Carbopol® 940 and 1.5% w/v HPMC E4M passed sterility test and demonstrated similar antimicrobial efficiency compared to commercial product. Conclusion: Carbopol®/HPMC-based in situ gels have potential to improve patient’s compliance by reducing the dosing frequency and could be a viable alternative to commercial product.]]> Mon 28 Nov 2022 17:15:27 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33966 Carbopol®=Chitosan. Permeation of the drug was increased in presence of chitosan. The antimicrobial activity of MF against Staphylococcus aureus and Streptococcus mutans were found to be enhanced with the developed formulations. The highest antimicrobial activity was observed with the chitosan-based formulations, due to the synergic effect of chitosan itself. Our results showed that chitosan based formulation is a promising local delivery system for treatment of periodontal disease by increasing the effect of the drug due to its mucoadhesive and penetration enhancing effect as well its antimicrobial activity Furthermore, with these properties the developed formulations will provide reduced frequency of administration, which result in higher patient compliance.]]> Fri 25 Jan 2019 14:42:26 AEDT ]]>